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KMID : 0620920090410030171
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Experimental & Molecular Medicine
2009 Volume.41 No. 3 p.171 ~ p.179
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Resveratrol inhibits foam cell formation via NADPH oxidase 1- mediated reactive oxygen species and monocyte chemotactic protein-1
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Park Dae-Weon
Baek Kheewoong
Kim Jae-Ryong
Lee Jae-Jin
Ryu Sang-Ho
Chin Byung-Rho
Baek Suk-Hwan
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Abstract
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Resveratrol is a polyphenolic compound in red wine that has anti-oxidant and cardioprotective effects in animal models. Reactive oxygen species (ROS) and monocyte chemotactic protein-1 (MCP-1) play key roles in foam cell formation and atherosclerosis. We studied LPS-mediated foam cell formation and the effect of resveratrol. Resveratrol pretreatment strongly suppressed LPS-induced foam cell formation. To determine if resveratrol affected the expression of genes that control ROS generation in macrophages, NADPH oxidase 1 (Nox1) was measured. Resveratrol treatment of macrophages inhibited LPS-induced Nox1 expression as well as ROS generation, and also suppressed LPS-induced MCP-1 mRNA and protein expression. We investigated the upstream targets of Nox1 and MCP-1 expression and found that Akt-forkhead transcription factors of the O class (FoxO3a) is an important signaling pathway that regulates both genes. These inhibitory effects of resveratrol on Nox1 expression and MCP-1 production may target to the Akt and FoxO3a signaling pathways.
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KEYWORD
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atherosclerosis, CCL2 protein, foam cells, FoxO3a protein, NADPH oxidase 1, reactive oxygen species, resveratrol
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